Abstract: Using MOD13Q1 as the data source, by adopting the analysis method of fixed starting year and increased ending years, and supplemented by Sen+Mann-Kendall slope method and Hurst index methods, the characteristics and driving forces of the changes of vegetation cover in Hangjin County from 2000-2017 was investigated. The results show that: (1) the spatial distribution pattern of vegetation cover in Hangjin County showed "high-low-high" trend from north to south; a greening-browing trend was observed in the significantly increased area of normalized difference vegetation index (NDVI), while the degraded area had a first downward and then upward trend; (2) the mean NDVI value presented an order: agricultural land > forest > shrub > grassland > sandland under the different land use types, and the increase rate of NDVI in forest, shrub and grassland was significant while sandy land was the lowest; (3) the main trend of NDVI in the study area is degradation, accounting for 57.93% of the total area of the Hangjin County, and precise measures should be taken to strengthen ecological protection in this region; (4) precipitation had a positive effect on NDVI, whereas temperature did not promote vegetation grown and the correlation decreased with time period lengthening; and human activities had a dual effect on NDVI; (5) the driving forces of each period exhibited a complicated status gradually, and the interactions of climate variations and human activities had significant effects on NDVI.